Do genes determine your fat loss destiny? A guest post by Dr. Lisa Vaughan, Osteo

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Hello, Fat Burning Babes worldwide!

I'm excited to have Dr. Lisa Vaughan, Osteopath, here to share her mindblowing expertise on Nutrigenomics. Make yourself a cuppa joe and settle in for this fascinating read.

Nutrigenomics is a scientific discipline that studies the interaction between genes, diet, lifestyle choices, and -- for today's purpose -- how it impacts your ability to burn fat, reverse gene expression and reclaim your health.

Full disclosure. I began working with Dr. Vaughan when she chose to do a three month SystemShred private physique transformation journey after hitting many frustrating "diet" dead ends. One of the many joys of working with women all over the world is how much they teach me!

Dr. Vaughan took full ownership of her physique transformation program by incorporating her expertise into her own individual gene expression to achieve fantastic results. Here she is after only four months of SystemShred Private Physique Transformation Coaching.

No Fail Physique Transformation Before and After

Dr. Lisa Vaughan. Four (4) month No Fail SystemShred Physique Transformation

Well worth the investment in herself! And now.... Here's Dr. Vaughan (


It's true that you can't change your inherited genes; however, you can compensate for their influence by choosing better nutritional matches for your genes. A good computing analogy is that, in essence, nutrigenetics determines your body's hardware and nutrigenomics determines the software i.e. the messages that are sent out.

In short, gene expression is modifiable; your genes are NOT your destiny, you can repair DNA damage and improve the functioning of your genes by making the right nutrition, exercise and lifestyle choices.Dr. Lisa Vaughan Nutrigenomics No Fail Physique Transformation for Women

When I run a DNA profile for clients, I determine their phenotype, which is the sum total of all your visual aspects as a result of the interaction of your genotype (genes) and your environment.


Why is Nutrigenomics Important?

Globally, healthcare systems are facing major challenges as we're in the midst of a global epidemic of preventable lifestyle diseases. As well as having this epidemic of preventable diseases, such as obesity, diabetes, heart disease and Alzheimer's, we have an aging population. Consequently, even though life expectancy has increased, health expectancy for living in good health is decreasing. 

Factors Contributing to Health Expectancy Decline

Historically, the major factors contributing to the decline in health expectancy have been:

  1. Lack of appropriate exercise;

  2. Food quality and quantity;

  3. Smoking;

  4. Alcohol and/or drugs;

  5. Stress;

  6. Environmental factors such as air and water pollution, use of chemicals in the home.

    However, NOW the most important factor is:

  7. Interaction of your genes with your environment and lifestyle choices.

The importance of the interactions of your genes with your lifestyle choices in the current obesogenic environment has been highlighted by an Australian Federal Government report released in May 2009, titled 'Weighing it up - Obesity in Australia', which stated that environmental and lifestyle factors contribute about 30% to an individual's body weight and genetics contributes the other 70%.

Personalised healthcare requires information that is specific to the individual and not just 'one size fits all'. Since the human genome was sequenced in 2000, there has been an expectation that genetic testing would prove the answer to a lot of medical questions. It has largely failed to deliver on this, to date. However, now that the science community has begun to understand what some genes do and how their expression can be modified, more meaningful healthcare solutions are being identified and delivered. Profiling for variations in key genes of major physiological pathways provides the basis for personalised interventions. Linking an individual's genetic signature with familial and personal health history and pathology testing can assist healthcare practitioners to identify an individual's predisposition to certain health risks and those who may benefit from early exercise, nutrition and lifestyle interventions, before clinical symptoms appear.

What a DNA Profile Reveals in Regard to Fat Loss Success

When we look at weight management, glucose and insulin control, research proves several genes are extremely important. Of course, the genes of fat metabolism are important; however, the Inflammatory genes are fundamental as well. We now know most of our Western chronic diseases are connected to a state of Chronic inflammation.

Here's a perfect example of one of my patients who previously attempted ketogenic dieting to no avail. I explain the graphic below for your reference.

Dr. Lisa Vaughan Nutrigenomics No Fail Physique Transformation for Women

  • FAB2 strongly influences how one absorbs fat. Having orange and red dots (being heterozygous or homozygous) causes the carrier to absorb dietary fat more rapidly and more completely. The aim of intervention is to down regulate the activity of this gene. Interventions include regular exercise, avoiding a high fat diet and moderating carbohydrate intake.
  • PPARy regulates fat metabolism, energy storage, insulin sensitivity and glucose control. Carriers with red and orange dots have decreased enzyme activity therefore interventions involve increasing activity. This is done by regular exercise decreasing alcohol as this inhibits this gene. Zinc up regulates activity as does Omega 3 fish oils.
  • PPARgC1A: Critical in the maintenance of glucose fat and energy homeostasis. Aim of intervention is to increase this genes activity. Interventions include exercise, avoiding alcohol, exercising in the cold, moderating fat and carbohydrate intake.
  • MC4R super important in body weight regulation especially in women. Aim is to up regulate receptor activity. Interventions include avoiding a high fat diet which decreases activity and avoiding overeating
  • FTO is what I call the fatso gene. Strongly associated with poor control over eating: i.e. over eating. Those with this variation tend to go for high carb and fatty foods. Interventions include portion control, exercise is crucial for those with this variation.
  • LEP1 and 2 regulates appetite and control. Carriers with these variations tend to overeat and develop leptin resistance. There is conflicting data as to the interventions but carb restricting seems to be helpful.
  • ADRbeta2 and 3 are involved in how one actually burns fat for fuel. Carriers tend to have difficulty burning fat and have decreased carbohydrate tolerance. Interventions include HIIT, resistance training and monitoring carbohydrate intake.
  • UPCP1 and 3-2 involves how one burns fat for heat. Carriers have difficulty mobilising fat for heat. Intervention involves resistance exercise, including seaweed in the diet, tea, Vit A and not severely restricting food. Avoid severely restricting fats as a high fat diet increases UCP1 expression

So, we see Client X has variations in FAB2, PPARgC1A, FTO, ADRbeta2 and 3 and UCP1. This implies she absorbs fat easily, has trouble burning it for fuel and heat and has a tendency to overeat or even binge eat. She has tried a ketogenic diet and intermittent fasting with average to poor results. We understand why now.

For Client X specifically, a more moderate (and strategically timed) carbohydrate, lower fat, moderate protein protocol will result in an impressive  fat loss and lean tissue building transformation. This, coupled with resistance training and well-timed metabolic conditioning, will do dramatic wonders. This is also why I believe so strongly in a scientifically proven nutrition and training protocol like SystemShred.

Dr. Lisa Vaughan, Osteopath


P.S. Interested in having Dr. Vaughan perform a DNA profile for you? Email her at and give your fat loss goals every chance for success!

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